Surgical Outcomes in Peripheral Nerve Sheath Tumors: Insights from an Institutional Experience with Literature Review

Abstract

Background : Peripheral nerve sheath tumors (PNSTs) encompass schwannomas, neuro-fibromas, and the more aggressive malignant PNSTs (MPNSTs). This study aimed to evaluate the clinical presentation and surgical morbidity associated with PNST excision.

Methods : This retrospective study aims to assess outcomes over the past 10 years atour institution following surgical excision of PNSTs, focusing on the extent of resection,neurological deficits, the need for nerve grafting, and postoperative requirements forchemotherapy and radiotherapy.

Results : A palpable lump was the most common symptom, painful in 57% andassociated with numbness in 35.7%. Gross total resection was achieved in 78.57% ofcases. Histopathology revealed schwannomas in 78.57%, neurofibromas in 14.28%, andone case (7.2%) of MPNST. Two patients required sural nerve grafts. Postoperative motor weakness occurred in two cases, both improved. The mean follow-up duration inthe study was 6.5 years, during which no tumor recurrences were observed

.Conclusion : PNSTs are relatively common and should be managed at specializedcenters by experienced surgeons to ensure safe resection, minimal postoperativedeficits, and excellent outcomes with low recurrence rates.